Bicyclic furo pyrimidine nucleosides with aryloxyphenyl and halophenyl substituted side chains as potent and selective Varicella-Zoster Virus inhibitors

Authors
Blewett, S McGuigan, C Barucki, H Andrei, G Snoeck, R De Clercq, E Balzarini, J
Citation
S. Blewett et al., Bicyclic furo pyrimidine nucleosides with aryloxyphenyl and halophenyl substituted side chains as potent and selective Varicella-Zoster Virus inhibitors, NUCLEOS NUC, 20(4-7), 2001, pp. 1063-1066
Citations number
7
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1063 - 1066
Database
ISI
SICI code
1525-7770(2001)20:4-7<1063:BFPNWA>2.0.ZU;2-S
Abstract
The discovery of potent and selective inhibitors of VZV based on unusual bi cyclic alkyl furo pyrimidine nucleosides has been recently reported. Modifi cations to the side-chain by addition of a phenyl group were found to furth er enhance the antiviral potency of these compounds. A series of alkoxyphen yl compounds (5a-5g) and two halophenyl derivatives (5h and 5i) were succes sfully synthesised and displayed anti-VZV activity at low muM concentration s.