The design and synthesis of purine inhibitors of CDK2. III

Authors
Shum, PW Peet, NP Weintraub, PM Le, TB Zhao, Z Barbone, F Cashman, B Tsay, J Dwyer, S Loos, PC Powers, EA Kropp, K Wright, PS Bitonti, A Dumont, J Borcherding, DR
Citation
Pw. Shum et al., The design and synthesis of purine inhibitors of CDK2. III, NUCLEOS NUC, 20(4-7), 2001, pp. 1067-1078
Citations number
9
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1067 - 1078
Database
ISI
SICI code
1525-7770(2001)20:4-7<1067:TDASOP>2.0.ZU;2-C
Abstract
Cyclin-dependent kinases (CDKs) belong to a class of enzymes that control t he ability of a cell to enter into and proceed through the cell division cy cle. Using purine as a scaffold, we have synthesized a number of nanomolar inhibitors of CDK-2/cyclin E. In this report, the synthesis of a series of piperidine-substituted purine analogs will be presented, as well as some of their in vitro and in vivo biological effects.