Citation
Dt. Hickman et al., Kinetically selective binding of single stranded RNA over DNA by a pyrrolidine-amide oligonucleotide mimic (POM), NUCLEOS NUC, 20(4-7), 2001, pp. 1169-1172
Citations number
11
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770
→ ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1169 - 1172
Database
ISI
SICI code
1525-7770(2001)20:4-7<1169:KSBOSS>2.0.ZU;2-8
Abstract
Replacing the sugar-phosphodiester backbone of nucleic acids with a pyrroli
dine-amide backbone results in an oligonucleotide mimic POM 1 which binds w
ith high affinity and specificity to complementary DNA and RNA. Unlike othe
r modified oligonucleotides, PONT binds much more rapidly to single strande
d RNA than DNA.