Engineering preferences of hairpin PNA binding to complementary DNA: Effect of N7G in aeg/aep PNA backbone

Authors
Kumar, VA D'Costa, M Ganesh, KN
Citation
Va. Kumar et al., Engineering preferences of hairpin PNA binding to complementary DNA: Effect of N7G in aeg/aep PNA backbone, NUCLEOS NUC, 20(4-7), 2001, pp. 1187-1191
Citations number
6
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1187 - 1191
Database
ISI
SICI code
1525-7770(2001)20:4-7<1187:EPOHPB>2.0.ZU;2-7
Abstract
AegPNA and aepPNA monomeric units bearing the N7-guanine nucleobase as a su bstitute for C+ have been demonstrated to bind to a GC base-pair of a duple x in a pH-independent manner when placed in the third strand. The aepPNA ba ckbone exerts a preference for binding in the antiparallel Hoogsteen mode o ver the parallel Hoogsteen mode.