Constrained flexibility in PNA: DNA binding studies with bridged aminopropylglycyl PNA

Authors
Lonkar, PS Kumar, VA Ganesh, KN
Citation
Ps. Lonkar et al., Constrained flexibility in PNA: DNA binding studies with bridged aminopropylglycyl PNA, NUCLEOS NUC, 20(4-7), 2001, pp. 1197-1200
Citations number
8
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1197 - 1200
Database
ISI
SICI code
1525-7770(2001)20:4-7<1197:CFIPDB>2.0.ZU;2-U
Abstract
Introduction of methylene bridges in aegPNA and apgPNA molecules give rise to cyclic five and six membered ring structures. Synthesis of a new six mem bered cyclic PNA monomer, aminopipecolyl PNA (pipPNA) is reported. Incorpor ation of pipPNA into PNA oligomers and comparative binding with target DNA sequences is studied.