Ql. Song et Ys. Sanghvi, Unexpected results and recourse in process optimization of nucleoside 3 '-O-succinates, NUCLEOS NUC, 20(4-7), 2001, pp. 1267-1270
An improved and scalable protocol for the synthesis of 3'-O-succinates of n
ucleosides has been developed using succinic anhydride. As a result, format
ion of unwanted dimer has been completely eliminated and use of toxic and s
melly reagents have been avoided during synthesis of nucleoside succinates.
All succinates were isolated in pure state without silica gel column chrom
atography.