Unexpected results and recourse in process optimization of nucleoside 3 '-O-succinates

Authors
Song, QL Sanghvi, YS
Citation
Ql. Song et Ys. Sanghvi, Unexpected results and recourse in process optimization of nucleoside 3 '-O-succinates, NUCLEOS NUC, 20(4-7), 2001, pp. 1267-1270
Citations number
9
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1267 - 1270
Database
ISI
SICI code
1525-7770(2001)20:4-7<1267:URARIP>2.0.ZU;2-D
Abstract
An improved and scalable protocol for the synthesis of 3'-O-succinates of n ucleosides has been developed using succinic anhydride. As a result, format ion of unwanted dimer has been completely eliminated and use of toxic and s melly reagents have been avoided during synthesis of nucleoside succinates. All succinates were isolated in pure state without silica gel column chrom atography.