Parallel DNA containing pyrazolo[3,4-D]pyrimidine analogues of isoguanine

Authors
Seela, F Kroschel, R He, Y
Citation
F. Seela et al., Parallel DNA containing pyrazolo[3,4-D]pyrimidine analogues of isoguanine, NUCLEOS NUC, 20(4-7), 2001, pp. 1283-1286
Citations number
10
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1283 - 1286
Database
ISI
SICI code
1525-7770(2001)20:4-7<1283:PDCPAO>2.0.ZU;2-#
Abstract
The phosphoramidites of 8-aza-7-deaza-2'-deoxyisoguanosine (1a) and its bro mo derivative 1b as well as of 6-aza-2-deoxyisocytidine and its 5-methyl de rivative (3a,b) were synthesized. Parallel-stranded duplexes containing the nucleosides 1a,b show a significantly enhanced duplex stability compared t o those containing 2'-deoxyisoguanosine.