Large-scale manufacturing of all four 2 '-deoxynucleosides via novel strategies including a chemo-enzymatic process

Authors
Komatsu, H Awano, H Tanikawa, H Itou, K Ikeda, I
Citation
H. Komatsu et al., Large-scale manufacturing of all four 2 '-deoxynucleosides via novel strategies including a chemo-enzymatic process, NUCLEOS NUC, 20(4-7), 2001, pp. 1291-1293
Citations number
4
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1291 - 1293
Database
ISI
SICI code
1525-7770(2001)20:4-7<1291:LMOAF2>2.0.ZU;2-W
Abstract
A chemical synthesis of 2-deoxyribose-1-phosphate 2 and its enzymatic conve rsion into purine 2'-deoxynucleosides (dNus) are shown. Besides the chemoen zymatic process for purine dNus, a modified process for practical dC prepar ation is also established. Consequently, a series of practical manufacturin g processes of all four dNus have been realized via novel strategies.