Synthesis and biological activities of cyclic ADP-carbocyclic-ribose and its analogs

Authors
Fukuoka, M Shuto, S Minakawa, N Ueno, Y Matsuda, A
Citation
M. Fukuoka et al., Synthesis and biological activities of cyclic ADP-carbocyclic-ribose and its analogs, NUCLEOS NUC, 20(4-7), 2001, pp. 1355-1358
Citations number
10
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1355 - 1358
Database
ISI
SICI code
1525-7770(2001)20:4-7<1355:SABAOC>2.0.ZU;2-5
Abstract
An efficient synthesis of cyclic ADP-carbocyclic-ribose (2), as a stable mi mic for cyclic ADP-ribose, was achieved. Treatment of N-1-carbocyclic-ribos yladenosine bisphosphate derivative 10 with AgNO3 in the presence of molecu lar sieves 3A in pyridine gave the desired cyclic product in 93% yield, whi ch was deprotected to give the target cyclic ADP-carbocyclic-ribose (2).