Preparation of 3 '-C-branched uridine analogues, suitable for conversion into functionalism 3 '-C-methylene derivatives

Authors
Winqvist, A Stromberg, R
Citation
A. Winqvist et R. Stromberg, Preparation of 3 '-C-branched uridine analogues, suitable for conversion into functionalism 3 '-C-methylene derivatives, NUCLEOS NUC, 20(4-7), 2001, pp. 1389-1392
Citations number
14
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1389 - 1392
Database
ISI
SICI code
1525-7770(2001)20:4-7<1389:PO3'UA>2.0.ZU;2-S
Abstract
A novel method for preparation of 1-[2-O-(tert-butyldimethylsilyl)-3-deoxy- 3-C-hydroxymethyl-5-O-monomethoxytrityl-beta -D-ribo-pentofuranosyl]uracil by hydroboration of corresponding 3'-deoxy-3'-C'-methyleneuridine derivativ e has been developed. Further conversion of the hydroxyl function into diff erent leaving groups was carried out to afford derivatives suitable for con version into various 3'-C-branched uridine analogues through substitution.