Phosphoramidites and oligonucleotides containing 7-deazapurines and pyrimidines carrying aminopropargyl side chains

Authors
Seela, F Ramzaeva, N Leonard, P Chen, Y Debelak, H Feiling, E Kroschel, R Zulauf, M Wenzel, T Frohlich, T Kostrzewa, M
Citation
F. Seela et al., Phosphoramidites and oligonucleotides containing 7-deazapurines and pyrimidines carrying aminopropargyl side chains, NUCLEOS NUC, 20(4-7), 2001, pp. 1421-1424
Citations number
12
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
4-7
Year of publication
2001
Pages
1421 - 1424
Database
ISI
SICI code
1525-7770(2001)20:4-7<1421:PAOC7A>2.0.ZU;2-O
Abstract
The synthesis of phosphoramidites containing 7-deazaguanine, 7-deazaadenine , uracil and cytosine carrying aminopropargyl chains is described. The corr esponding oligonucleotides are stabilized in duplexes thermally as well as against degradation by exonucleases.