We report an infant with Noonan syndrome who presented antenatally with pol
yhydramnios, edema, ascites and pericardial effusion. His mother has Noonan
syndrome. Postnatally, he was found to have clinical features compatible w
ith Noonan syndrome, and a right-sided pleural effusion was noted. This res
olved by day 12 without any intervention. This case is an example of the di
versity of clinical features of Noonan syndrome.