Tg. Dinan et al., Impact of cortisol on buspirone stimulated prolactin release: a double-blind placebo-controlled study, PSYCHONEURO, 26(7), 2001, pp. 751-756
Buspirone is known to stimulate prolactin release. Clinical studies (e.g. i
n chronic fatigue syndrome) suggest that the response may be influenced by
baseline cortisol levels. We conducted a double-blind placebo-controlled st
udy to examine the relationship between the prolactin response to buspirone
challenge and baseline cortisol level. Fifty healthy volunteers took part
in the study. Buspirone was found to consistently elevate PRL levels above
those seen following placebo administration. The PRL response as measured b
y area under the curve was highly correlated with the baseline cortisol lev
el. 2001 Published by Elsevier Science Ltd.