Biocatalysis in polymer-supported synthesis: Enzyme-labile linker groups

The development or new and broadly applicable linker groups which are stabl e under a variety of reaction conditions and allow release of the desired p roducts from polymeric supports under very mild conditions is of great inte rest for organic synthesis and combinatorial chemistry. In this review we s ummarize the results of the research activities directed towards the introd uction of enzyme-labile linkers which yield a variety of different target m olecules through enzymatic cleavage from different polymeric supports.