Optical biosensors. Monitoring studies of glycopeptide antibiotic fermentation using white light interference

This paper describes the design, characterization, and use of an optical bi osensor suited for the process control of biotechnological processes. The d etector principle is based on reflectometric interference spectroscopy (RIf S). RIfS enables a label-free, product-specific monitoring, with a future o utline for on-line process control. The potential of the RUS biosensor is e xemplified by the qualitative and quantitative monitoring of the microbial production of vancomycin-type glycopeptide antibiotics.