High- and moderately high-methionine uptake demonstrated by PET in a patient with a subacute cerebral infarction

In patients with cerebral tumors, high accumulations of L-methyl-C-11-methi onine (C-11-Met) have been reported in some cases of cerebral ischemic dise ase, but no high accumulations of C-11-Met in areas where only transient ar terial occlusions are most likely to occur have been reported. Herein we pr esent a case of a high accumulation of C-11-Met in an area of frontal inter hemispheric cerebral infarction and a moderately high accumulation with an unclear margin in a distant frontal convexity area. A craniotomy revealed a subacute stage of cerebral infarction in the interhemispheric lesion, and an ischemic change in the distant convexity area. Sixteen months after onse t, CT scans demonstrated an infarction area in the interhemispheric lesion only, and no atrophic changes were observed in the distant convexity area i ndicating that no serious tissue damage had occurred.