Biotransformation of malachite green by the fungus Cunninghamella elegans

Authors
Cha, CJ Doerge, DR Cerniglia, CE
Citation
Cj. Cha et al., Biotransformation of malachite green by the fungus Cunninghamella elegans, APPL ENVIR, 67(9), 2001, pp. 4358-4360
Citations number
28
Categorie Soggetti
Biology,Microbiology
Journal title
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
ISSN journal
00992240 → ACNP
Volume
67
Issue
9
Year of publication
2001
Pages
4358 - 4360
Database
ISI
SICI code
0099-2240(200109)67:9<4358:BOMGBT>2.0.ZU;2-Q
Abstract
The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized the tr iphenylmethane dye malachite green with a first-order rate constant of 0.02 9 mu mol h(-1) (mg of cells)(-1). Malachite green was enzymatically reduced to leucomalachite green and also converted to N-demethylated and N-oxidize d metabolites, including primary and secondary arylamines. Inhibition studi es suggested that the cytochrome P450 system mediated both the reduction an d the N-demethylation reactions.