M. Loh et al., Outcome of very premature infants with necrotising enterocolitis cared forin centres with or without on site surgical facilities, ARCH DIS CH, 85(2), 2001, pp. F114-F118
Objective-To determine if the presence of a neonatal surgical facility on s
ite has any effect on mortality and morbidity of very premature infants wit
h necrotising enterocolitis (NEC).
Design and Setting-Retrospective review of infants of less than 29 weeks ge
station cared for in the seven perinatal centres in New South Wales.
Patients-Between 1992 and 1997, 605 infants were cared for in two centres w
ith in house surgical facilities (group 1) and 1195 in five centres where t
ransfers were required for surgical management (group 2).
Results-Although use of antenatal steroids was significantly lower in group
1 centres than group 2 centres (74% v 85% respectively), and the incidence
of hyaline membrane disease, pneumothorax, and NEC was higher, mortality w
as identical (27%). Fifty two (9%) infants in group 1 and 72 (6%) in group
2 of comparable perinatal characteristics and CRIB (Clinical Risk Index for
Babies) scores developed radiologically or pathologically proven NEC. The
overall mortality of infants with NEC in group 1 was lower but this was not
statistically significant (27% v 35%). Significantly more infants with NEC
in group 1 had surgery (69% v 39%). There were fewer postoperative deaths
in group 1 and more deaths without surgery in group 2. The duration of resp
iratory and nutritional support and hospital stay for the survivors were si
milar in the two groups. In a multivariate analysis, shorter gestation was
the only factor associated with mortality in infants with NEC; the presence
of in house surgical facilities was not.
Conclusions-There were no significant differences in outcome of premature i
nfants with NEC managed in perinatal centres with or without on site surgic
al facilities. Early transfers should be encouraged. This finding may have
implications for future planning of facilities for neonatal care.