Pt. Nieuwkerk et al., Limited patient adherence to highly active antiretroviral therapy for HIV-1 infection in an observational cohort study, ARCH IN MED, 161(16), 2001, pp. 1962-1968
Citations number
29
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Background: Adherence to highly active antiretroviral therapy (HAART) for h
uman immunodeficiency syndrome type 1 (HIV-1) infection is essential to sus
tain viral suppression and prevent drug resistance. We investigated adheren
ce to HAART among patients in a clinical cohort study.
Methods: Patients receiving HAART had their plasma concentrations of protea
se inhibitors or nevirapine measured and completed a questionnaire on adher
ence, We determined the percentage of patients who reported taking all anti
retroviral medication on time and according to dietary instructions in the
past week. Drug exposure was compared between patients reporting deviation
from their regimen and fully adherent patients. Among patients who received
HAART for at least 24 weeks, we assessed the association between adherence
and virologic outcome.
Results: A total of 224 of 261 eligible patients completed a questionnaire.
Forty-seven percent reported taking all antiretroviral medication on time
and according to dietary instructions. Patients who reported deviation from
their regimen showed lower drug exposure compared with fully adherent pati
ents (median concentration ratio, 0.81 vs 1.07; P=.001). Among those receiv
ing HAART for at least 24 weeks, patients reporting deviation from their re
gimen were less likely to have plasma HIV-1 RNA levels below 500 copies/mL
(adjusted odds ratio, 4.0; 95% confidence interval, 1.4-11.6) compared with
fully adherent patients.
Conclusions: Only half of the patients took all antiretroviral medication i
n accordance with time and dietary instructions in the preceding week. Devi
ation from the antiretroviral regimen was associated with decreased drug ex
posure and a decreased likelihood of having suppressed plasma HIV-1 RNA loa
ds. Patient adherence should remain a prime concern in the management of HI
V-1 infection.