Hepatitis C virus (HCV) has high genomic variability and, since its discove
ry, at least six different types and an increasing number of sub-types have
been reported. Genotype 1 is the most prevalent genotype found in South Am
erica. Recent phylogenetic analysis of strains isolated in Uruguay revealed
the presence of a different genetic lineage from major sub-types 1a and 1b
. In order to study if type 1 HCV strains circulating in the South American
region can be associated with this genetic lineage, sequence data obtained
from the 5' non-coding region from 6 type 1 patients from Chile, were comp
ared with sequences obtained from 12 type 1 Uruguayan and 9 type 1 Brazilia
n patients as well as 17 different strains of all types isolated elsewhere.
The phylogenetic analysis revealed the existence of type 1 strains of this
novel genetic lineage in all South American countries studied, and indicat
es a diversification of HCV viruses in the South American region.