Selective, orally active MMP inhibitors with an aryl backbone

Authors
Barta, TE Becker, DP Bedell, LJ De Crescenzo, GA McDonald, JJ Mehta, P Munie, GE Villamil, CI
Citation
Te. Barta et al., Selective, orally active MMP inhibitors with an aryl backbone, BIOORG MED, 11(18), 2001, pp. 2481-2483
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
18
Year of publication
2001
Pages
2481 - 2483
Database
ISI
SICI code
0960-894X(20010917)11:18<2481:SOAMIW>2.0.ZU;2-P
Abstract
This letter describes SAR exploration and rat PK optimization of a series o f novel, MMP-1 sparing aryl hydroxamate sulfonamides with activity against MMP-2 and MMP-13. (C) 2001 Elsevier Science Ltd. All rights reserved.