Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES)

Authors
Ahmed, S James, K Owen, CP Patel, CK Patel, M
Citation
S. Ahmed et al., Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES), BIOORG MED, 11(18), 2001, pp. 2525-2528
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
18
Year of publication
2001
Pages
2525 - 2528
Database
ISI
SICI code
0960-894X(20010917)11:18<2525:HAPFIT>2.0.ZU;2-W
Abstract
We report the initial structure-activity relationship study (SAR) (in parti cular log P) of a series of compounds based upon 4-sulfamated phenyl ketone s as potent inhibitors of the enzyme estrone sulfatase (ES). The results of the study show that these compounds are irreversible inhibitors of ES and that they are more potent than COUMATE, but weaker than ENTATE. Analysis of the SAR data shows a strong correlation between IC50 and log P but also su pports our previous study, which suggests a very strong relationship betwee n pK(a) and IC50. (C) 2001 Elsevier Science Ltd. All rights reserved.