Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A(1)-adenosine receptor (A(1)AR) ligands

Authors
Schenone, S Bruno, O Fossa, P Ranise, A Menozzi, G Mosti, L Bondavalli, F Martini, C Trincavelli, L
Citation
S. Schenone et al., Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A(1)-adenosine receptor (A(1)AR) ligands, BIOORG MED, 11(18), 2001, pp. 2529-2531
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
18
Year of publication
2001
Pages
2529 - 2531
Database
ISI
SICI code
0960-894X(20010917)11:18<2529:SABDO4>2.0.ZU;2-W
Abstract
The synthesis of a new family of A(1)-adenosine receptor (A(1)AR) ligands 3 a-n has been performed in a straightforward way. Affinity data at A(1)AR, A (2)AAR and A(3)AR in bovine membranes show that these new compounds bind th e A(1)AR in a selective way over A(2A)AR and A(3)AR and one of them (3j) pr esents a very high affinity, probably due to the phenethylamine substituent at C-4. (C) 2001 Elsevier Science Ltd. All rights reserved.