Solid- and solution-phase synthesis of highly-substituted-pyrrolidine libraries

Citation
M. Steger et al., Solid- and solution-phase synthesis of highly-substituted-pyrrolidine libraries, BIOORG MED, 11(18), 2001, pp. 2537-2540
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
18
Year of publication
2001
Pages
2537 - 2540
Database
ISI
SICI code
0960-894X(20010917)11:18<2537:SASSOH>2.0.ZU;2-4
Abstract
Starting from a complex bicyclic beta -lactam scaffold we have demonstrated the possible production of libraries of a new class of drug-like, highly s ubstituted pyrrolidines. The choice of the type of substitution was made by optimizing various synthetic routes. The selection of each compound is the result of a filtration of a large virtual combinatorial chemical space, us ing simple criteria. The access to these complex pyrrolidines needed only f our to six synthetic steps. (C) 2001 Elsevier Science Ltd. All rights reser ved.