Enzymatic glycosylation of lincomycin

Authors
Weignerova, L Spizek, J Najmanova, L Kren, V
Citation
L. Weignerova et al., Enzymatic glycosylation of lincomycin, BIOS BIOT B, 65(8), 2001, pp. 1897-1899
Citations number
12
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451 → ACNP
Volume
65
Issue
8
Year of publication
2001
Pages
1897 - 1899
Database
ISI
SICI code
0916-8451(200108)65:8<1897:EGOL>2.0.ZU;2-M
Abstract
Lincomycin (1), a glycosidic antibiotic, active against Gram-positive bacte ria, was modified enzymatically with the aim of improving its physico-chemi cal and biological properties. Compound 1 was glycosylated using jack bean alpha -mannosidase to produce 7-O-alpha -D-mannopyranosyl-lincomycin (2).