Inhibitory effects of capsaicinoids on fatty acid desaturation in a rat liver cell line

Authors
Nakano, N Shirasaka, N Masuoka, K Murakami, T Watanabe, T Kobata, K Shimizu, S Yoshizumi, H
Citation
N. Nakano et al., Inhibitory effects of capsaicinoids on fatty acid desaturation in a rat liver cell line, BIOS BIOT B, 65(8), 2001, pp. 1859-1863
Citations number
25
Categorie Soggetti
Agricultural Chemistry","Biochemistry & Biophysics
Journal title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
ISSN journal
09168451 → ACNP
Volume
65
Issue
8
Year of publication
2001
Pages
1859 - 1863
Database
ISI
SICI code
0916-8451(200108)65:8<1859:IEOCOF>2.0.ZU;2-T
Abstract
The inhibitory effects of such vanillylamides as capsaicin and nine capsaic inoids on fatty acid desaturation in liver cells were investigated by using the cultured rat liver cell line, BRL-3A. When capsaicin was added to the medium, it had a relatively strong inhibitory effect on Delta6 desaturation and clear inhibitory effects on Delta5 and C24 Delta6 desaturation (Delta6 desaturation of C24-polyunsaturated fatty acids). Capsaicinoids with side carbon chain lengths of C10:0 and C12:0 expressed the maximum inhibitory ef fects of the nine capsaicinoids on fatty acid desaturation in the BRL-3A ce lls. The inhibitory effects of the capsaicinoids were not correlated with t heir pungency.