The role of endoscopic biopsy and third ventriculostomy in the management of pineal region tumours

The best surgical strategy for treating patients with pineal tumours presen ting with acute hydrocephalus remains undermined. During the past 17 years we have used transventricular endoscopic biopsy and third ventriculostomy a s a onestep procedure in the initial management of these cases, and present the largest consecutive case series illustrating the value of this techniq ue. We have successfully managed 34 consecutive patients with pineal region tumours, carrying out third ventriculostomy in 18 patients. Histological d iagnosis was obtained in 32/34 (94%) of the cases. There were no deaths or major complications and only one patient required a ventriculo-peritoneal s hunt owing to ventriculostomy failure. According to current management prot ocols and depending on histology, tumours were treated by a combination of resection via craniotomy followed by radiotherapy or chemotherapy, or by th e latter therapies alone. This one step procedure is minimally invasive and safely achieves adequate biopsy with control of hydrocephalus, whilst defi nitive histology and biochemical marker studies are obtained. Definitive tr eatment for each tumour is designed according to diagnosis.