Quality of life after low anterior resection with total mesorectal excision and temporary loop ileostomy for rectal carcinoma

Background: Low anterior resection (LAR) with total mesorectal excision (TM E) may be the optimal operation for carcinoma of the mid or lower rectum. R outine formation of a temporary defunctioning stoma has been recommended wi th TME. The impact of this strategy on health-related quality of fife (HRQO L) has not been addressed. Methods: A prospective longitudinal study was conducted among 24 patients u ndergoing LAR with TME and loop ileostomy for rectal cancer. Clinical outco mes were documented. HRQOL was assessed using Short Form 36 (SF-36). Twenty -three patients undergoing high anterior resection (HAR) for rectosigmoid c ancer were studied concurrently to determine the effects of major colorecta l resection without a stoma. Results: Time to resume normal diet, length of stay in hospital and time to return to non-work activities were similar after HAR or LAR with TME and l oop ileostomy. Twelve weeks after HAR SF-36 scores were stable or improved compared with preoperative levels. In contrast, 12 weeks after LAR + TME pa tients had a reduction in physical functioning scores on SF-36. SF-36 score s improved after ileostomy closure. Ileostomy closure increased total hospi tal stay and time off non-work activities. Conclusion: LAR with TME and temporary loop ileostomy for rectal cancer res ults in a long total hospital stay and impairs aspects of HRQOL. Prompt sto ma closure should be a priority in these patients.