Meningitis in infancy in England and Wales: follow up at age 5 years

Objective To describe important sequelae occurring among a cohort of childr en aged 5 years who had had meningitis during the first year of life and wh o had been identified by a prospective national study of meningitis in infa ncy in England and Wales between 1985 and 1987. Design Follow up questionnaires asking about the children's health and deve lopment were sent to general practitioners and parents of the children and to parents of matched controls. The organism that caused the infection and age at infection were also recorded. Setting England and Wales. Participants General practitioners and parents of children who had had meni ngitis before the age of 1 year and of matched controls. Main outcome measures The prevalence of health and developmental problems a nd overall disability among children who had had meningitis compared with c ontrols. Results Altogether, 1584 of 1717 (92.2%) children who had had meningitis mi d 1391 of 1485 (93.6'%) controls were successfully followed up, Among child ren who survived to age 5 years 247 of 1584 (15.6%) had a disability; there was a 10-fold increase in the risk of severe or moderate disability at 5 y ears of age among children who had had meningitis (relative risk 10.3, 95% confidence interval 6.7 to 16.0, P<0.001). There was considerable variation in the rates of severe or moderate disability in children infected with di fferent organisms. Conclusion The long term consequences of having meningitis during the first year of life are significant: 32 of 1717 (1.8%) children died within five years. Not only did almost a fifth of children with meningitis have a perma nent, severe or moderately severe disability, but subtle deficits were also more prevalent.