Disruption of protein-protein interactions: design of a synthetic receptorthat blocks the binding of cytochrome c to cytochrome c peroxidase

Authors
Wei, Y McLendon, GL Hamilton, AD Case, MA Purring, CB Lin, Q Park, HS Lee, CS Yu, TN
Citation
Y. Wei et al., Disruption of protein-protein interactions: design of a synthetic receptorthat blocks the binding of cytochrome c to cytochrome c peroxidase, CHEM COMMUN, (17), 2001, pp. 1580-1581
Citations number
16
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
17
Year of publication
2001
Pages
1580 - 1581
Database
ISI
SICI code
1359-7345(20010907):17<1580:DOPIDO>2.0.ZU;2-V
Abstract
Synthetic receptor I has been found via fluorescence titration to compete e ffectively with cytochrome c peroxidase for binding cytochrome c (Cc), form ing 1:1 Cc:1 complex with a binding constant of (3 +/- 1) X 10(8) M-1, and to disrupt Cc: Apaf-1 complex, a key adduct in apoptosis.