Synthesising protease-stable isopeptides by proteases: an efficient biocatalytic approach on the basis of a new type of substrate mimetics

Authors
Wehofsky, N Alisch, M Bordusa, F
Citation
N. Wehofsky et al., Synthesising protease-stable isopeptides by proteases: an efficient biocatalytic approach on the basis of a new type of substrate mimetics, CHEM COMMUN, (17), 2001, pp. 1602-1603
Citations number
23
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
17
Year of publication
2001
Pages
1602 - 1603
Database
ISI
SICI code
1359-7345(20010907):17<1602:SPIBPA>2.0.ZU;2-I
Abstract
A biocatalytic route to the 'post-synthesis' formation of Asp/Glu-derived i sopeptides is illustrated on the basis of the Staphylococcus aureus V8 prot ease used as the biocatalyst, a new type of substrate mimetics as the donor peptides, and several acceptor peptides varying in length and sequence.