A cascade radical-mediated macrocyclisation-transannulation approach to oestrogen steroids

Authors
Cardente, MAG McCulloch, S Pattenden, G
Citation
Mag. Cardente et al., A cascade radical-mediated macrocyclisation-transannulation approach to oestrogen steroids, CR AC S IIC, 4(7), 2001, pp. 571-574
Citations number
25
Categorie Soggetti
Chemistry
Journal title
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE
ISSN journal
13871609 → ACNP
Volume
4
Issue
7
Year of publication
2001
Pages
571 - 574
Database
ISI
SICI code
1387-1609(200107)4:7<571:ACRMAT>2.0.ZU;2-T
Abstract
A new approach to ring A aromatic steroids, based on cascade 13-endo-trig/d ig macrocyclisations followed by sequential 5-exo-trig and 6-exo-trig trans annulations, exemplified in the syntheses of the cis,anti,trans tetracycle 9 and the trans,sym tetracycle 13 from the ortho-substituted aryl polyen(yn e) precursors, 8 and 12 respectively, is described. (C) 2001 Academie des s ciences / Editions scientifiques et medicales Elsevier SAS.