SYNTHESIS OF 2-CHLOROETHYLNITROSOSULFAMIDES (CENS) VIA A TRANSSULFAMOYLATION REACTION

Authors
ABDAOUI M DEWYNTER G AOUF N MONTERO JL
Citation
M. Abdaoui et al., SYNTHESIS OF 2-CHLOROETHYLNITROSOSULFAMIDES (CENS) VIA A TRANSSULFAMOYLATION REACTION, Phosphorus, sulfur and silicon and the related elements, 118, 1996, pp. 39-47
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Phosphorus, sulfur and silicon and the related elements → ACNP
ISSN journal
10426507
Volume
118
Year of publication
1996
Pages
39 - 47
Database
ISI
SICI code
1042-6507(1996)118:<39:SO2
Abstract
In order to synthesize the series of 2-chloroethylnitrososulfamides (C ENS), a procedure using the nucleophilic exchange of an activating gro up of both the sulfamoyl esters and amides by several amines was devel oped. The N-oxysuccinimide sulfamate ester was revealed as the most re active sulfamoyl group donor. This transsulfamoylation procedure allow s the preparation of title compounds, especially the derivatives of am ino acid esters in two steps in a 75-80% yield.