Integrin tyrosine phosphorylation in platelet signaling

Authors
Phillips, DR Prasad, KSS Manganello, J Bao, M Nannizzi-Alaimo, L
Citation
Dr. Phillips et al., Integrin tyrosine phosphorylation in platelet signaling, CURR OP CEL, 13(5), 2001, pp. 546-554
Citations number
59
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
09550674 → ACNP
Volume
13
Issue
5
Year of publication
2001
Pages
546 - 554
Database
ISI
SICI code
0955-0674(200110)13:5<546:ITPIPS>2.0.ZU;2-O
Abstract
The beta3 integrin cytoplasmic tyrosine (ICY) motif of alpha IIb beta3 beco mes tyrosine phosphorylated during platelet aggregation, causing Shc and my osin to interact with the beta -integrin cytoplasmic domain. Platelets from mice lacking beta3 ICY motif tyrosines formed defective aggregates and poo rly retracted clots, establishing integrin tyrosine phosphorylation as a ke y mediator of beta3-integrin signals.