Leukocyte transendothelial migration: orchestrating the underlying molecular machinery

Authors
Worthylake, RA Burridge, K
Citation
Ra. Worthylake et K. Burridge, Leukocyte transendothelial migration: orchestrating the underlying molecular machinery, CURR OP CEL, 13(5), 2001, pp. 569-577
Citations number
97
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
09550674 → ACNP
Volume
13
Issue
5
Year of publication
2001
Pages
569 - 577
Database
ISI
SICI code
0955-0674(200110)13:5<569:LTMOTU>2.0.ZU;2-O
Abstract
Transendothelial migration of leukocytes involves the spatiotemporal regula tion of adhesion molecules, chemokines and cytoskeletal regulators. Recent results show that distinct steps of leukocyte transendothelial migration ar e regulated by sequential integrin activation and coordinated Rho family GT Pase activity. Progress has been made in understanding how the dynamic regu lation of these molecules translates into leukocyte transmigration.