FK506 facilitates chemical kindling induced by pentylenetetrazole in rats

Authors
Suzuki, K Omura, S Ohashi, Y Kawai, M Iwata, Y Tani, K Sekine, Y Takei, N Mori, N
Citation
K. Suzuki et al., FK506 facilitates chemical kindling induced by pentylenetetrazole in rats, EPILEPSY R, 46(3), 2001, pp. 279-282
Citations number
13
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
EPILEPSY RESEARCH
ISSN journal
09201211 → ACNP
Volume
46
Issue
3
Year of publication
2001
Pages
279 - 282
Database
ISI
SICI code
0920-1211(200109)46:3<279:FFCKIB>2.0.ZU;2-I
Abstract
To clarify the possible role played by calcineurin in kindling development, we examined the effects of pretreatment with FK506, a selective calcineuri n inhibitor, on pentylenetetrazole (PTZ) kindling in rats. FK506 facilitate d the speed of kindling induced by repeated administration of 30-mg/kg PTZ, while FK506 did not ameliorate acute seizure manifestations after a single injection of PTZ. Our results suggested that calcineurin might exert an in hibitory effect on PTZ kindling. (C) 2001 Elsevier Science B.V. All rights reserved.