Aw. Bruijnzeel et al., LY354740 attenuates the expression of long-term behavioral sensitization induced by a single session of foot shocks, EUR J PHARM, 426(1-2), 2001, pp. 77-80
Exposure of rats to a single session of foot shocks sensitizes behavioral r
esponses to novel stimuli. There is evidence that metabotropic glutamate (m
Glu) receptors play a role in sensitization processes. In the present study
, we investigated the role of mGlu(2/3) receptors in the long-term (14 days
) increase in defensive withdrawal behavior after a single session of foot
shocks. Exposure to foot shocks increased defensive withdrawal behavior. Th
e mGlu(2/3) receptor agonist LY354740 ((1S,2S,5R,6S)-(+)-2-aminobicyclo[3.1
.0]hexane-2,6-dicarboxylic acid, 0.1 mg/kg, i.p.) normalized the increased
latency and the decreased time in the light of the preshocked rats. We conc
lude that activation of mGlu(2/3) receptors attenuates the foot shock-induc
ed expression of behavioral sensitization. (C) 2001 Elsevier Science B.V. A
ll rights reserved.