The selective sigma(1) receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl) piperazine (SA4503), blocks the acquisition of the conditioned place preference response to (-)-nicotine in rats

Authors
Horan, B Gardner, EL Dewey, SL Brodie, JD Ashby, CR
Citation
B. Horan et al., The selective sigma(1) receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl) piperazine (SA4503), blocks the acquisition of the conditioned place preference response to (-)-nicotine in rats, EUR J PHARM, 426(1-2), 2001, pp. R1-R2
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
426
Issue
1-2
Year of publication
2001
Pages
R1 - R2
Database
ISI
SICI code
0014-2999(20010824)426:1-2<R1:TSSRA1>2.0.ZU;2-4
Abstract
We examined the effect of the sigma (1) receptor agonist, 1-(3,4-dimethoxyp henethyl)-4-(phenylpropyl)piperazine (SA4503), on the acquisition of the co nditioned place preference response to subcutaneously administered (-)-nico tine in rats. (-)-Nicotine, but not SA4503 or vehicle, produced a significa nt conditioned place preference response. Pretreatment of animals with eith er 1 or 3 mg/kg of SA4503 significantly attenuated the conditioned place pr eference response to)-nicotine. (C) 2001 Published by Elsevier Science B.V.