Three-dimensional patterns of lung tumor growth: Association with tumor heterogeneity

Citation
N. Tripodis et P. Demant, Three-dimensional patterns of lung tumor growth: Association with tumor heterogeneity, EXP LUNG R, 27(6), 2001, pp. 521-531
Citations number
19
Categorie Soggetti
da verificare
Journal title
EXPERIMENTAL LUNG RESEARCH
ISSN journal
01902148 → ACNP
Volume
27
Issue
6
Year of publication
2001
Pages
521 - 531
Database
ISI
SICI code
0190-2148(200109)27:6<521:TPOLTG>2.0.ZU;2-S
Abstract
Most histological classifications of lung tumors assess information derived from 2-dimensional surfaces. However, tumors grow in 3 dimensions in a var iety of architectural patterns that possibly reflect the histological type or progression status of the tumor. A new mathematically derived variable ( Rratio) is presented, that assesses the overall 3-dimensional shape of a tu mor and classifies tumors based on their sphericality. Analysis and compari son of groups of spherical and nonspherical tumors fi-om mouse inbred strai ns and recombinant congenic strains with a strict set of predetermined hist ological criteria shows that Rratio is significantly associated with tumor heterogeneity and that histological differences exist between the spherical and nonspherical tumors. These results suggest that Rratio may be a valuab le tool for the characterization of tumors and can be used to explore quali tative differences in tumors derived from segregating crosses.