Role of probiotics in inflammatory bowel disease and intestinal infections

Bacteria are present throughout the GI tract but their pattern and concentr ations vary greatly. Probiotics are living microorganisms that belong to th e normal intestinal flora and are important to the health and well-being of the host. The concept of probiotic therapy is still controversial; there a re many data from in vitro and animal studies, however, to date the benefic ial effects of probiotics in humans have mostly been demonstrated under poo rly defined experimental conditions. Several experimental and clinical obse rvations suggest a role for the intestinal microflora in inflammatory bowel disease (IBD) pathogenesis and there is increasing evidence supporting the potential therapeutic role for probiotics in the treatment of IBD. The use of probiotics to treat GI infections has produced contrasting results; the ir efficacy in the prevention or treatment of infective diarrhoea was evalu ated in a large number of studies; however, the most convincing evidence of their benefit concerns rotavirus infection in children. Future research ne eds to focus on obtaining more precise information on the composition of th e enteric microflora and the mechanisms of action of probiotics.