Birth after intracytoplasmic sperm injection with use of testicular sperm from men with Kartagener/immotile cilia syndrome

Objective: To describe two cases of in vitro fertilization (TVF) and intrac ytoplasmic sperm injection (ICSI) with testicular sperm in men with immotil e cilia syndromes. Design: Case report. Setting: A university-based male infertility clinic and assisted reproducti on unit. Patient(s): Two couples with male factor infertility due to Kartagener/immo tile cilia syndrome. Intervention(s): IVF/ICSI with testicular sperm. Main outcome measure(s): Semen characteristics, sperm viability, fertilizat ion rate, and pregnancy. Result(s): With testicular sperm, the two pronuclear fertilization rates we re 63% and 60% in two cases. One case resulted in the birth of normal healt hy girl. Conclusion(s): With testicular sperm, successful oocyte fertilization after ICSI in couples with male Kartagener/immotile cilia syndrome is possible d espite the lack of sperm motility. (Fertil Steril(R) 2001;76:612-14. (C) 20 01 by American Society for Reproductive Medicine).