Townes-Brocks syndrome versus expanded spectrum hemifacial microsomia: Review of eight patients and further evidence of a "hot spot" for mutation in the SALL1 gene

Citation
Ce. Keegan et al., Townes-Brocks syndrome versus expanded spectrum hemifacial microsomia: Review of eight patients and further evidence of a "hot spot" for mutation in the SALL1 gene, GENET MED, 3(4), 2001, pp. 310-313
Citations number
24
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
GENETICS IN MEDICINE
ISSN journal
10983600 → ACNP
Volume
3
Issue
4
Year of publication
2001
Pages
310 - 313
Database
ISI
SICI code
1098-3600(200107/08)3:4<310:TSVESH>2.0.ZU;2-3
Abstract
Purpose: It can be difficult to differentiate clinically between hemifacial microsomia (HFM) and Townes-Brocks syndrome (TBS). The distinction is impo rtant because TBS is inherited as an autosomal dominant trait, whereas HFM is sporadic. Methods: We performed a retrospective analysis of eight patien ts with HFM-expanded spectrum and anal anomalies to determine whether this subset has TBS. Results: Two patients had major phenotypic findings of TBS. Sequencing of SALL1, the gene mutated in TBS, in four of the eight patient s revealed one with a C --> T transition (resulting in a nonsense mutation R276X) at a previously identified mutational "hot spot." Conclusion: Patien ts with overlapping features of both syndromes should be screened for SALL1 mutations.