Stereoselective synthesis of a novel tetracyclic beta-lactam

Authors
Pyun, DK Jung, HJ Kwak, HJ Kim, JH Kim, EJ Kim, BJ Kim, MH Lee, CH
Citation
Dk. Pyun et al., Stereoselective synthesis of a novel tetracyclic beta-lactam, HETEROCYCLE, 55(7), 2001, pp. 1253
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
55
Issue
7
Year of publication
2001
Database
ISI
SICI code
0385-5414(20010701)55:7<1253:SSOANT>2.0.ZU;2-G
Abstract
Stereocontrolled total synthesis of a novel tetracyclic beta -lactam (3) ha s been achieved in ten steps. The key transformations in this approach are the regioselective ring opening of beta -epoxide (5 beta) and the stereosel ective construction of ketoazetidinone (11) from methoxyketo-gamma -lactam (9) and 4-acetoxyazetidinone (10).