The 49a,f haplotype 11 is a new marker of the EU19 lineage that traces migrations from northern regions of the Black Sea

Previous studies on human Y-chromosome polymorphisms in the European popula tions highlighted the high frequency of the 49a,f/TaqI haplotype I I and of the Eu19 (M17) lineage in Eastern Europe. To better understand the origin and the evolution of the Eu19, and its relationship with 49a,f Ht11, this s tudy surveyed 2,235 individuals (mainly from Europe and the Middle East) fo r the 49a,f Ht I I and for many biallelic markers defining the Eu19 lineage . As previously described, the highest frequency of Eu19 was found in Easte rn Europe. All the Eu19 Y-chromosomes turned out to be 49a,f Ht11 or its de rivatives, the distribution of which suggests that the Eu19/49a,f Ht11 emer ged in Ukraine, probably in a Palaeolithic population. Thereafter, the spre ad of this lineage toward Europe, Asia, and India occurred at different wav es over a few thousands years. At present this seems to indicate the influe nce of the Ukraine Palaeolithic groups in the gene pool of modern populatio ns. For the first time it is possible to make inferences about the evolutio n of some haplotypes of the 49a,f system. In spite of its unknown molecular base, this is one of the first most informative polymorphisms of the Y chr omosome. Human Immunology 62, 922-932 (2001) (C) American Society for Histo compatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.