In vitro antifungal activity of posaconazole against various pathogenic fungi

The antifungal activity of posaconazole (SCH56592), a new triazole antifung al, against stock cultures and fresh clinical isolates of a wide range of p athogenic fungi was compared with that of itraconazole, fluconazole and amp hotericin B. Posaconazole inhibited growth of all the fungal species tested except Fusarium spp. at 1 mg/l or lower concentrations, showing a broad-sp ectrum antifungal activity. The activities of posaconazole for all the fung al species far surpassed those of fluconazole and were even superior to tho se of itraconazole for Aspergillus spp. as well as for many other fungal sp ecies. (C) 2001 Elsevier Science B.V. and International Society of Chemothe rapy. All rights reserved.