Prenatal exposure to alcohol affects the cytoskeleton in the developing rat liver

Citation
I. Azorin et al., Prenatal exposure to alcohol affects the cytoskeleton in the developing rat liver, INT J DEV B, 45, 2001, pp. S151-S152
Citations number
4
Categorie Soggetti
Cell & Developmental Biology
Journal title
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
ISSN journal
02146282 → ACNP
Volume
45
Year of publication
2001
Supplement
1
Pages
S151 - S152
Database
ISI
SICI code
0214-6282(2001)45:<S151:PETAAT>2.0.ZU;2-M
Abstract
Prenatal alcohol exposure alters the liver and induces pathological changes in the morphology and function of the Golgi apparatus (GA), including an a ccumulation or reduced transport of newly synthesized glycoconjugates which suggests that ethanol could affect the cytoskeleton (CSK) in hepatocytes. To test this possibility we have analysed, using various techniques, the ef fect of ethanol "in utero" on several CSK proteins including actin, alpha- tubulin, cytokeratin, vimentin and the motor associated proteins dynein and kinesin. Our results show that this treatment increases the amount of both alpha -tubulin and cytokeratin and alters its distribution.