Clinical practice guidelines provide a means to enhance physician performan
ce. This investigation was undertaken in an attempt to understand the natur
e of impact of guideline use on physician performance. We investigated the
impact of (a) algorithmic-based and (b) text-based practice guidelines on c
linical decision-making by physicians at varying levels of expertise. Data
were collected using clinical scenarios and a think-aloud paradigm, both wi
th (primed) and without (spontaneous) the use of the guidelines. The two gu
idelines used in the study were management of diabetes and screening for th
yroid disease. The results show that guidelines were used as reminders for
both experts and non-experts. Guidelines acted as an educational tool for n
on-experts by assisting in knowledge reorganization, particularly for the n
on-experts. Text and algorithmic guideline formats were both useful to phys
ician performance depending on the purpose of use: solving clinical problem
s or learning. These results provide insights into how guidelines can be fi
ne-tuned for different users and for different purposes. Empirical research
, coupled with design principles from the cognitive sciences, can form an e
ssential component of guideline design and development. (C) 2001 Elsevier S
cience Ireland Ltd. All rights reserved.