Despite major advances in inotropic medications and our understanding of th
eir proper use, surgical management of heart failure is the fastest-g owing
aspect of cardiovascular surgery. In addition to causing 750,000 deaths an
nually, myocardial infarctions leave an estimated 60,000 more patients in s
evere congestive heart failure and several times more individuals with comp
romised ventricular function. As these patients are offered reparative surg
ical options, surgeons, anesthesiologists, and cardiologists face physiolog
ic challenges that can be optimally overcome only by modifying treatment st
rategies to address patients who have failed appropriate medical therapy, i
ncluding milrinone, vasopressin, and nitric oxide. As our comfort with mech
anical support increases, the threshold for embarking on these lines of tre
atment will be altered. Innovative devices have been created to meet this c
linical need, but they must provide adequate quality of life to create sust
ainable value and health for society.