D. Schweer et al., No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis, J NEUROIMM, 118(2), 2001, pp. 300-303
Alpha-2-macroglobulin (A2M) is a proteinase inhibitor involved in deactivat
ion of cytokines and modulation of antigen-mediated immune responses. Based
on its role in inflammatory and neurodegenerative disorders. we investigat
ed the role of A2M and its receptor low-density lipoprotein receptor-relate
d protein (LRP) for the development of multiple sclerosis (MS). We analyzed
the frequency of two polymorphisms in the A2M (Val 1000 Ile, Exon 18 del),
and one polymorphism in the LRP (A216V) gene in a case control study invol
ving 326 MS patients, and 290 controls. all defined for the expression of H
LA-DR15. No association was found for any of the three polymorphism with MS
. Furthermore. no differences in serum A2M levels were detected between MS
patients and controls. The results do not suggest a contribution of A2M and
LRP to the development of MS. (C) 2001 Elsevier Science B.V. All rights re
served.