High-dose omeprazole in esophagitis with stenosis after surgical treatmentof esophageal atresia

The authors describe 4 children with recurrent stenosis and persistent esop hagitis after secondary repair of a long gap esophageal atresia. They under went an esophageal reconstruction by elongation of the lesser gastric curva ture according to Scharli at the age of 11 to 14 months. All had esophagiti s grade III to IV (Savary-Miller classification), esophageal stenosis, and failure to thrive. Effective treatment of the esophagitis and prevention of stenosis consisted in high doses of omeprazole (1.9 to 2.5 mg/kg/d). After this treatment, the need for esophageal dilatation disappeared, and nutrit ional status normalized. J Pediatr Surg 36.,1416-1418. Copyright (C) 2001 b y W.B. Saunders Company.